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evolence

Evolence - A New Collagen Replacement

Note: Evolence is no longer available. It was a great product but wasn't able to beat out the recession. Dr. Sikorski has a wide array of alternatives, including Cosmoderm and Cosmoplast for those who prefer collagens.

Wouldn’t it be great to be able to replace the collagen so we’d look more like our more youthful selves? As nature's most fundamental and abundant building block, collagen makes up 70% to 80% of the skin's support system, providing structure, strength, and smoothness. Collagen is naturally depleted over time with age, leading to wrinkles, folds, loss of volume and a slack appearance to the skin.

Your treatment with Evolence Collagen Facial Filler

  • Achieves immediate, natural-looking results
  • Causes minimal-to-no swelling or bruising, so you can get right back to daily activities. 99% of patients have a full resolution of any swelling by the next day.
  • Is the first collagen filler to last for up to 12 months, so there are no costly repeat treatments every few months
  • Achieves longevity through a unique manufacturing process called GLYMATRIX™ Technology, which cross-links the collagen with a natural sugar, not synthetic chemicals or substances
  • Does not require a skin pre-test

In a clinical survey, 97% of patients reported being "satisfied" or "very satisfied" with their EVOLENCE® filler results.

The Difference between Collagen Replacements and Hyaluronic Acid Gel Fillers

Hyaluronic acid fillers absorb and retain water to create their effect. They work well but their method of support once in the skin is not the same a collagen.
EVOLENCE® is a structural agent that utilizes a three-dimensional collagen matrix. Collagen tends to create less reactive swelling and has a lower tendency to cause bruising. This collagen structure benefits patient because it lessens bruising and swelling that usually results following injection of dermal fillers. EVOLENCE® also does not use chemicals for cross-linking but instead uses natural sugar to improve durability.

Collagens have never had a reputation for durability (some of you will recall the short time span of bovine and human collagens) despite the fact they achieved their purpose in "wrinkle filling". The really nice thing about Evolence is it’s longevity – thus far at least 6 months and in many cases much longer.

A Collagen with Durability

Derived from porcine sources and cross linked with sugar, Evolence is very similar to your own natural collagen structure so you body doesn’t break it down as quickly as older less compatible collagen products. Used as an added support to the existing collagen structures still present in your skin, the effects and feel are indistinguishable from your own natural collagen.


Source Evolence
Johnson&Johnson  / OrthoNeutrogena

Evolence has been used in Canada, Europe and other countries since 2004 and has a proven safety and duration record with effects lasting 6 to 12 months. There is no need for pre-testing so patients may receive injections of Evolence whenever they wish. Evolence uses the same biological source material that has been used in heart, dental, and eye surgery for decades and has FDA approval as a dermal filler.

Star Training for Evolence

It's important to choose a STAR trained physician if you decide to try Evolence. The providers of Evolence, Johnson & Johnson, require specific training of their dispensing physicians so that patients will receive all the possible benefits from their use of the product.

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Where is Evolence used?

  • Deep folds on the sides of the mouth - nasolabial folds
  • Marionette lines
  • Downturned mouth corners (and age “giveaway”)
  • Potential use in the lips and for vertical lip lines - under evaluation with Evolence
  • Breeze (not yet available in the US)


Photo Source Evolence - Johnson & Johnson/OrthoNeutrogena
Photos Show Patient 12 hours after injection
to demonstrate lack of swelling or bruising
View the Evolence Website

Pre-Treatment Tips

  • Avoid blood thinners, anti-inflammatories such as ibuprofen, herbal medications, vitamin E and aspirin, and red wine 5 days prior to treatment. Please check with your primary physician before stopping any recommended medications.
  • Have water or food prior to your appointment as you will be advised to let the treated area rest for about 4 hours after.

After The Treatment

  • Note: no alcohol for 24 hours after treatment
  • No increased blood pressure (i.e. sauna, hot tub, exercise, cardio) for 4 hours post treatment (Helps prevent bruising)
  • It is recommended that make up not be applied until 1 hour after treatment to allow the skin to breathe
  • Avoid excessive facial expressions and strenuous exercise for 4 hours after your treatment. (This helps the product to "settle" without disturbing the location where it was injected.)
  • Do not rub or massage the area for 24 hours.
  • Redness and swelling may last for 1-2 days
  • There is a risk of bruising which is only temporary and can be covered up with make-up.
  • Evolence® provides effect for an average of 6-9 months. This effect varies depending on the type of skin, areas, and amounts injected. A follow up procedure 2-4 weeks after the initial treatment helps to lengthen the duration and optimize the results.

Evolence in the News


European Aesthetic Buyers Guide

Can I use Evolence with other fillers or BOTOX® Cosmetic?

BOTOX® Cosmetic is proving to be an ideal partner treatment with fillers. By using BOTOX® Cosmetic along with your wrinkle fillers, they'll both last longer. It appears that by minimizing muscle contraction with BOTOX® Cosmetic, the effects from your filler injections last longer. Mixing and matching fillers often works well in creating a "wardrobe" of appearance helpers.

For instance, Radiesse can offer contouring, JUVÉDERM® Injectable Gel can be used in the lip border and lip itself and Sculptra can restore volume loss. The end effects of the different components, is in fact, very similar to putting together a complete outfit. Each piece plays a part in the total finished effect.

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